Furthermore emphysematous bullae may rupture under an elevated pressure, hence COPD is a relative contra-indication to hyperbaric oxygen therapy.Ī search of Pubmed found nothing published on the management of carbon monoxide poisoning in patients with chronic obstructive lung disease, and clearly a careful balance needs to be found between the level of administered oxygen, the patient's pCO 2, and the required rate of clearance of CO. This markedly raises the arterial oxygen level, and in COPD patients prone to CO 2 retention would clearly cause significant elevation of pCO 2. The gold standard treatment for severe CO poisoning is hyperbaric oxygen therapy. Our difficulty in the above case was that the patient almost certainly had undiagnosed COPD, and hence when high-flow oxygen was given – the preferred initial management strategy – the patient retained CO 2 and became increasingly obtunded, necessitating a reduction in the FiO 2, and hence prolonging the clearance of carbon monoxide. CO elimination has a dependent relationship with the FiO 2: in room air the half-life of COHb is up to 5 hours with high-flow oxygen and a reservoir mask this reduces to approximately 70 minutes and hyperbaric oxygen reduces this further to about 25 minutes. The initial aims are removal from the source, and administration of high-flow oxygen. Management depends on the severity of the poisoning. Levels of COHb correlate poorly with clinical features, but it is generally accepted that an initial level of greater than 15% suggests significant toxicity. ![]() There is a spectrum of clinical features from headache, nausea, and flu-like symptoms through to coma with hyperventilation, convulsions, pulmonary oedema, myocardial ischaemia and cherry-red skin colouring. CO has approximately 240 times the affinity of oxygen for binding to haemoglobin, and forms the COHb complex which impairs tissue oxygen delivery, inhibits mitochondrial oxidative phosphorylation, and inactivates cytochrome oxidase. While almost certainly under-diagnosed, there are nearly 200 documented serious poisonings every year in the UK, occurring most commonly from house fires, faulty gas heaters and car exhausts. Both patients were observed overnight and were discharged the following morning with no short-term ill effects of their exposure.Ĭarbon monoxide (CO) is a tasteless, odourless gas resulting from incomplete combustion. Repeat measurements four hours later showed that the patient's COHb level had dropped to 5%, while his non-smoking wife had a level of only 1%. A later arterial blood gas analysis showed normalisation of the pCO 2 level.īlood results were unremarkable apart from a COHb level of 9% (NR < 2%), compared with his wife who had no symptomatology or clinical signs, but an initial COHb level of 11%. With the substitution of controlled flow oxygen at 0.24 FiO 2 the patient rapidly became more alert, and despite persistent oxygen saturations of 94%, suffered no subjective or objective dyspnoea. Over the next hour the patient became increasingly difficult to rouse and a repeat arterial blood gas analysis showed a pH of 7.32 and a raised pCO 2 of 7.80 kPa. ![]() High-flow oxygen at 15 litres/minute with a reservoir bag was recommenced as the patient's pulse oximeter saturations fell to 92% on air. Oxygen was removed, and a subsequent arterial blood gas analysis showed pH 7.4 (NR 7.35–7.45), pO 2 10.1 kPa (NR > 10.6), and pCO 2 of 5.46 kPa (NR 4.6–6.0). The patient was oriented but drowsy with a GCS of 14/15, losing a point for eye-opening. Initial blood pressure was 139/84, pulse 74 beats per minute, and pulse oximeter saturations of 100% on high-flow oxygen. However the patient was expectorating carbonaceous sputum. There was no family history of note, and the patient was a non-drinker but had a significant smoking history of at least 20 cigarettes per day for over 50 years, and was a current smoker.Įxamination revealed no evidence of external burns, facial burns, singed nostril hair, hoarseness, stridor, or overt evidence of airway obstruction. Medications were bendrofluazide, amlodipine, metformin, atorvastatin, and a multivitamin. ![]() ![]() Past medical history included hypertension, type 2 diabetes, L4/5 disc prolapse. Following rescue by the fire brigade and initial high-flow oxygen therapy by the ambulance service, the man arrived at hospital drowsy and less responsive than he had been at the scene. Smoke rose through the floors and windows, and the patient and his wife were exposed to significant smoke inhalation. The flat below his had caught fire during the night, awakening the patient and his family. A 70 year-old retired man presented to the Emergency Department following a house fire.
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